Organic low-dimensional heterostructures consisting of multicomponent solids interface together and hold promising potential in advancing optoelectronic applications based on various excited-state processes between different materials at the cross sections. However, these profitable organic low-dimensional heterostructures are not readily available, and some key issues need to be settled, such as how to design and construct organic low-dimensional heterostructures with desired physicochemical properties from the molecular to the structural level. Furthermore, how various excited-state processes at the interface of the junctions influence the regulation of optoelectronic performance also needs to be studied. This review systematically discusses recent advances in the above issues with a purpose to provide a timely overview of this fascinating field. Finally, we propose a comprehensive conclusion and some forward-looking perspectives in the hope of promoting the continuous investigation in this research field. Organic low-dimensional heterostructures consisting of multicomponent solids interface together and hold promising potential in advancing optoelectronic applications based on various excited-state processes between different materials at the cross sections. However, these profitable organic low-dimensional heterostructures are not readily available, and some key issues need to be settled, such as how to design and construct organic low-dimensional heterostructures with desired physicochemical properties from the molecular to the structural level. Furthermore, how various excited-state processes at the interface of the junctions influence the regulation of optoelectronic performance also needs to be studied. This review systematically discusses recent advances in the above issues with a purpose to provide a timely overview of this fascinating field. Finally, we propose a comprehensive conclusion and some forward-looking perspectives in the hope of promoting the continuous investigation in this research field.