医学
胸腺瘤
标准摄取值
PET-CT
氟脱氧葡萄糖
阶段(地层学)
恶性肿瘤
正电子发射断层摄影术
接收机工作特性
放射科
核医学
内科学
外科
生物
古生物学
作者
Bahar Ağaoğlu Şanlı,Elif Duman,Barış Gülmez,Nurşin Agüloğlu,Serkan Yazgan,Kenan Can Ceylan,Ahmet Üçvet
出处
期刊:Nuclear Medicine Communications
[Ovid Technologies (Wolters Kluwer)]
日期:2023-12-28
卷期号:45 (3): 236-243
标识
DOI:10.1097/mnm.0000000000001805
摘要
Purpose In recent years, the use of fluorodeoxyglucose PET-computed tomography (PET-CT) has become widespread to evaluate the diagnosis, metabolism, stage and distant metastases of thymoma. In this study, it was aimed to investigate the connection of malignancy potential, survival and maximum standardized uptake value (SUV max ) measured by PET-CT before surgery according to the histological classification of the WHO in patients operated for thymoma. In addition, the predictive value of the Glasgow prognostic score (GPS) generated by C-reactive protein (CRP) and albumin values on recurrence and survival was investigated and its potential as a prognostic biomarker was evaluated. Methods Forty-five patients who underwent surgical resection for thymoma and were examined with PET-CT in the preoperative period between January 2010 and January 2022 were included in the study. The relationship between WHO histological classification, tumor size and SUV max values on PET-CT according to TNM classification of retrospectively analyzed corticoafferents were evaluated. Preoperative albumin and CRP values were used to determine GPS. Results The cutoff value for SUV max was found to be 5.65 in the patients and the overall survival rate of low-risk (<5.65) and high-risk (>5.65) patients was compared according to the SUV max threshold value (5.65) and found to be statistically significant. In addition, the power of PET/CT SUV max value to predict mortality (according to receiver operating characteristics analysis) was statistically significant ( P = 0.048). Survival expectancy was 127.6 months in patients with mild GPS (O points), 96.7 months in patients with moderate GPS (1 point), and 25.9 months in patients with severe GPS (2 points). Conclusion PET/CT SUV max values can be used to predict histological sub-type in thymoma patients, and preoperative SUV max and GPS are parameters that can provide information about survival times and mortality in thymoma patients.
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