锌指
转录因子
调节器
生物
转录调控
癌症研究
胚胎干细胞
负调节器
细胞生物学
遗传学
基因
信号转导
作者
Qing Xie,Chang Tong,Xiangyang Xiong
出处
期刊:Life Sciences
[Elsevier]
日期:2024-01-01
卷期号:336: 122314-122314
标识
DOI:10.1016/j.lfs.2023.122314
摘要
Nucleus accumbens-associated protein 1 (NACC1) is a member of the broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein families, mainly exerting its biological functions as a transcription co-regulator. NACC1 forms homo- or hetero-dimers through the BTB/POZ or BANP, E5R, and NACC1 (BEN) domain with other transcriptional regulators to regulate downstream signals. Recently, the overexpression of NACC1 has been observed in various tumors and is positively associated with tumor progression, high recurrence rate, indicating poor prognosis. NACC1 also regulates biological processes such as embryonic development, stem cell pluripotency, innate immunity, and related diseases. Our review combines recent research to summarize advancements in the structure, biological functions, and relative molecular mechanisms of NACC1. The future development of NACC1 clinical appliances is also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI