塞马3A
再生(生物学)
坐骨神经
轴突
神经科学
刺激
神经损伤
去神经支配
医学
坐骨神经损伤
解剖
生物
细胞生物学
内科学
受体
信号灯
作者
Xianbin Wang,Shouxing Hu,Shuai Ouyang,Xiao‐Pan Ma,Yingxue Fu,Xingyu Chen,Shuang Wu
标识
DOI:10.1016/j.neulet.2024.137691
摘要
Enhancing axonal regeneration is one of the most important processes in treating nerve injuries. Both magnetic and electrical stimulation have the effect of promoting nerve axon regeneration. But few study has investigated the effects of trans-spinal magnetic stimulation (TsMS) combined with electroacupuncture (EA) on nerve regeneration in rats with sciatic nerve injury. In this study, we compared the improvement of neurological function in rats with sciatic nerve crush injuries after 4 weeks of different interventions (EA, TsMS, or TsMS combined with EA). We further explored the morphological and molecular biological alterations following sciatic nerve injury by HE, Masson, RT-PCR, western blotting, immunofluorescence staining and small RNA transcriptome sequencing. The results showed that TsMS combined with EA treatment significantly promoted axonal regeneration, increased the survival rate of neurons, and suppressed denervation atrophy of the gastrocnemius muscle. Subsequent experiments suggested that the combination treatment may play an active role by mediating the miR-539-5p/Sema3A/PlexinA1 signaling axis.
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