Association of CD58 rs12044852 and rs2300747 polymorphisms with the risk of multiple sclerosis: A systematic review and meta-analysis

荟萃分析 单核苷酸多态性 优势比 医学 多发性硬化 子群分析 等位基因 遗传模型 置信区间 遗传关联 多重比较问题 遗传学 肿瘤科 内科学 基因 基因型 生物 免疫学 统计 数学
作者
Arif Ahmed,A.E. Maisha Rawshan,Zasia Hossain Tishe,Sara Shawkat,Meherun Nessa Popy,Md Hasanuzzaman Shohag,Murad Hossain,Md Shaki Mostaid
出处
期刊:Multiple sclerosis and related disorders [Elsevier BV]
卷期号:82: 105411-105411
标识
DOI:10.1016/j.msard.2023.105411
摘要

Abstract

Objective

Multiple sclerosis is a serious neurodegenerative disorder that causes disability in young adults. Genetic predisposition of multiple sclerosis is well documented and several single nucleotide polymorphisms (SNPs) of the CD58 were found to be associated with this disease. This systematic review and meta-analysis were done with the aim of finding the association between CD58 gene SNPs (rs12044852 and rs2300747) and the risk of multiple sclerosis (MS).

Method

A comprehensive search was done in PubMed, Google Scholar, Embase, and MSGene.org to find the relevant data. Our search yielded 13 relevant publications which were included for meta-analysis consisting of 5194 cases and 5766 controls. All the statistical analysis was conducted using meta and metafor packages in R studio. The odds ratios (OR) along with 95% confidence intervals and p values were determined using the fixed effects and random effects model. The I2 test was done to measure heterogeneity. Subgroup analysis was performed along with analysis for publication bias.

Results

We found significant association for both rs12044852 (allelic, dominant, over-dominant, heterozygous, and homozygous models) and rs2300747 (allelic, dominant, over-dominant, heterozygous models) with multiple sclerosis. Both the SNPs provide a protective effect for multiple sclerosis. Subgroup analysis indicated that rs12044852 polymorphism provided a protective effect in both Asians and Caucasians. However, for rs2300747, the Asian population showed no statistically significant association with the risk of MS.

Conclusion

Polymorphism of rs12044852 and rs2300747 of the CD58 gene provided a protective effect for multiple sclerosis. The protective effect is more prominent in Caucasian populations compared to Asians.
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