医学
队列
颞下颌关节
人口
入射(几何)
颅面
关节炎
疼痛
纵向研究
队列研究
儿科
累积发病率
前瞻性队列研究
牙科
物理疗法
内科学
病理
精神科
物理
环境卫生
光学
作者
Mia Glerup,Aikaterini Tagkli,Annelise Küseler,Anne Estmann Christensen,Carlalberta Verna,Anders Ellern Bilgrau,Sven Erik Nørholt,Troels Herlin,Thomas Klit Pedersen,Peter Stoustrup
摘要
Objectives 1) To estimate the cumulative incidences of orofacial conditions related to temporomandibular joint (TMJ) juvenile idiopathic arthritis (JIA) between diagnosis in childhood to transition into adult care. 2) To identify features in JIA associated with TMJ involvement. Methods A population-based cohort analysis was conducted of patients with JIA involving longitudinal data on orofacial health from 2000 to 2018. Regardless of TMJ status, the patients were referred to the Regional Craniofacial Clinic of Western Denmark for routine orofacial examinations. Data collection included information about disease-specific background information, TMJ involvement, JIA-induced dentofacial deformity, and orofacial symptoms and dysfunction. Results A total of 613 patients were followed with a mean clinical TMJ observation time of 4.0 years. From JIA onset to transition into adult care, the cumulative incidence of patients with JIA involvement of the TMJ was 30.1%. Furthermore, 20.6% of the cohort had developed arthritis-induced dentofacial deformity. A substantial proportion of the cohort experienced several events with orofacial symptoms (23.5%) and dentofacial dysfunction (52%). The following baseline variables were significantly adversely associated with TMJ involvement: young age at diagnosis (< 9 years), female gender, and antinuclear antibody (ANA) positivity. Conclusions Orofacial signs and symptoms were frequent findings in children and adolescents with JIA. TMJ involvement was seen in 30.1% of the cohort; and 20.6% of the total cohort developed JIA-related dentofacial deformity before transition into adult care. This is the first population-based study in the biologic era to document these frequent orofacial complications in children with JIA.
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