Microglial forkhead box O3a deficiency attenuates LPS‐induced neuro‐inflammation and depressive‐like behaviour through regulating the expression of peroxisome proliferator‐activated receptor‐γ

Depression is closely linked with microglial activation and neuro-inflammation. Peroxisome proliferator-activated receptor-γ (PPAR-γ) plays an important role in M2 activation of microglia. Forkhead box (FOX) O3a has been implicated in the regulation of mood-relevant behaviour. However, little is known about the inflammatory mechanisms of in the microglia of the brain. Here, we have investigated the role of microglial FOXO3a/PPAR-γ in the development of depression.