Pioneering polysaccharide extraction with deep eutectic solvents: A review on impacts to extraction yield, physicochemical properties and bioactivities

Deep eutectic solvents (DES) have emerged as promising solvents for polysaccharide extraction from various sources. The DES which is produced by combining hydrogen bond donors and acceptors offers sustainability, low toxicity, a wide range of solubility and tailored properties. This review examines DES features and their effectiveness as extraction media for polysaccharides, highlighting the mechanisms behind their enhanced extraction efficiency compared to classical solvents. Additionally, we discuss the mechanism behind the DES affecting the physicochemical and structural properties of the extracted polysaccharides. The review also explores the antioxidant, antihyperglycemic, antihyperlipidemic and immunomodulatory properties of DES-extracted polysaccharides compared to classical solvents which emphasize structural changes in the polymer complex. This review intends to shed insight into the prospects of green extraction technologies by providing information on the benefits of DES and its potential to modify polysaccharide characteristics and enhance their biological activities, which is covered in depth for the first time here.