Amino acid metabolism in breast cancer: Pathogenic drivers and therapeutic opportunities

乳腺癌 谷氨酰胺 生物 氨基酸 代谢组学 癌症 代谢途径 谷氨酰胺酶 谷氨酰胺分解 计算生物学 新陈代谢 生物信息学 癌症研究 生物化学 遗传学
作者
Yawen Liu,Xiangyun Zong,Patricia Altea‐Manzano,Jie Fu
出处
期刊:Protein & Cell [Springer Nature]
标识
DOI:10.1093/procel/pwaf011
摘要

Abstract Amino acid metabolism plays a critical role in the progression and development of breast cancer. Cancer cells, including those in breast cancer, reprogram amino acid metabolism to meet the demands of rapid proliferation, survival, and immune evasion. This includes alterations in the uptake and utilization of amino acids such as glutamine, serine, glycine, and arginine, which provide essential building blocks for biosynthesis, energy production, and redox homeostasis. Notably, the metabolic phenotypes of breast cancer cells vary across molecular subtypes and disease stages, emphasizing the need for patient stratification and personalized therapeutic strategies. Advances in multi-level diagnostics, including phenotyping and predictive tools such as AI-based analysis and body fluid profiling, have highlighted the potential for tailoring treatments to individual metabolic profiles. Enzymes such as glutaminase and serine hydroxymethyltransferase, often upregulated in breast cancer, represent promising therapeutic targets. Understanding the interplay between amino acid metabolism and breast cancer biology, alongside the integration of personalized medicine approaches, can uncover novel insights into tumor progression and guide the development of precision therapies. This review explores the metabolic pathways of amino acids in breast cancer, with a focus on their implications for personalized treatment strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可耐的三德完成签到 ,获得积分10
刚刚
刚刚
1秒前
脑洞疼应助浮生采纳,获得10
1秒前
1秒前
茜茜完成签到,获得积分10
1秒前
佳2完成签到,获得积分10
1秒前
橙子快跑发布了新的文献求助10
2秒前
昏睡的蟠桃应助97采纳,获得20
2秒前
冷静凌翠发布了新的文献求助10
3秒前
脑洞疼应助古德猫宁采纳,获得10
3秒前
请叫我风吹麦浪应助木皆采纳,获得10
3秒前
GGbond发布了新的文献求助10
3秒前
马楼发布了新的文献求助10
4秒前
发酱完成签到,获得积分10
4秒前
笃定发布了新的文献求助10
5秒前
科研通AI5应助小王采纳,获得30
5秒前
小二郎应助Be-a rogue采纳,获得10
5秒前
麒麟完成签到,获得积分10
5秒前
活泼雁芙发布了新的文献求助10
5秒前
席半完成签到,获得积分10
5秒前
满眼星辰发布了新的文献求助10
6秒前
kento应助Erised采纳,获得200
7秒前
852应助橙子快跑采纳,获得10
7秒前
7秒前
佳2发布了新的文献求助10
8秒前
Purple完成签到,获得积分10
8秒前
10秒前
GGbond完成签到,获得积分10
10秒前
12秒前
oldfe发布了新的社区帖子
12秒前
stqs完成签到,获得积分20
12秒前
Tim发布了新的文献求助10
12秒前
13秒前
Coconut应助活力忆秋采纳,获得10
14秒前
14秒前
畅快平凡发布了新的文献求助10
14秒前
冷静凌翠完成签到,获得积分10
15秒前
15秒前
李健的小迷弟应助3939采纳,获得10
15秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
Teaching language in context (Third edition) by Derewianka, Beverly; Jones, Pauline 550
Oligomycin, a new antifungal antibiotic 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3583447
求助须知:如何正确求助?哪些是违规求助? 3152668
关于积分的说明 9493793
捐赠科研通 2855215
什么是DOI,文献DOI怎么找? 1569480
邀请新用户注册赠送积分活动 735260
科研通“疑难数据库(出版商)”最低求助积分说明 721145