Chemical Ligation-Mediated Total Synthesis of Corramycin

The ligation-mediated total synthesis of corramycin, a myxobacterial natural product of the strain Corallococcus coralloides, is presented. The synthetic strategy included using two consecutive chemical ligations for a modular and efficient preparation. Finally, the synthesis employed a Ser/Thr ligation (STL) at a new ligation site combined with classical fragment coupling. This study provides the total synthesis of corramycin and enhances the preparative toolbox of STL in organic synthesis.