Framework Nucleic Acid‐Based Nanomaterials: A Promising Vehicle for Small Molecular Cargos

Chapter 3 Framework Nucleic Acid-Based Nanomaterials: A Promising Vehicle for Small Molecular Cargos Yanjing Li, Yanjing Li Tianjin Medical University School and Hospital of Stomatology, Department of Prosthodontics, 12 Qixiangtai Road, Tianjin, 300070 PR ChinaSearch for more papers by this author Yanjing Li, Yanjing Li Tianjin Medical University School and Hospital of Stomatology, Department of Prosthodontics, 12 Qixiangtai Road, Tianjin, 300070 PR ChinaSearch for more papers by this author Book Editor(s):Yunfeng Lin, Yunfeng Lin Sichuan University, West China College of Stomatology State Key Laboratory of Oral Diseases, No. 14, 3rd Section of RenMin Nan Road, Chengdu, 610041 PR, ChinaSearch for more papers by this authorShaojingya Gao, Shaojingya Gao Sichuan University, West China College of Stomatology State Key Laboratory of Oral Diseases, No. 14, 3rd Section of RenMin Nan Road, Chengdu, 610041 PR, ChinaSearch for more papers by this author First published: 26 April 2024 https://doi.org/10.1002/9783527841912.ch3 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Framework nucleic acids (FNAs), which are a series of self-assembled DNA nanostructures, are highly versatile tools for engineering intelligent molecular delivery vehicles. Owing to their precise and controllable design and construction, excellent programmability and functionality, as well as favorable intercalation between DNA and small molecules, FNAs provide a promising approach for small molecule delivery. This review discusses the advantages, applications, and current challenges of FNAs for the delivery of small molecular cargos. First, the physicochemical and biological properties that make FNAs favorable for the transport of small molecules are introduced. Thereafter, the classification of loaded cargos and the mechanism of combination between small molecules and FNAs are summarized in detail, and recent research on FNA-based delivery systems and their applications is highlighted. Finally, the challenges and prospects of FNA nanocarriers are discussed to advance their exploitation and clinical adoption. References Seeman , N.C. ( 1982 ). Nucleic acid junctions and lattices . J. Theor. 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