Additive Manufacturing of Wet‐Spun Poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)‐Based Scaffolds Loaded with Hydroxyapatite

生物相容性 脚手架 材料科学 组织工程 热重分析 PLGA公司 复合数 生物医学工程 聚己内酯 差示扫描量热法 聚合物 复合材料 抗压强度 化学工程 纳米技术 医学 物理 纳米颗粒 冶金 热力学 工程类
作者
Gianni Pecorini,Simona Braccini,Stefano Simoni,Andrea Corti,Gianluca Parrini,Dario Puppi
出处
期刊:Macromolecular Bioscience [Wiley]
卷期号:24 (6)
标识
DOI:10.1002/mabi.202300538
摘要

Tissue engineering represents an advanced therapeutic approach for the treatment of bone tissue defects. Polyhydroxyalkanoates are a promising class of natural polymers in this context thanks to their biocompatibility, processing versatility, and mechanical properties. The aim of this study is the development by computer-aided wet-spinning of novel poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)-based composite scaffolds for bone engineering. In particular, PHBV scaffolds are loaded with hydroxyapatite (HA), an osteoinductive ceramic, in order to tailor their biological activity and mechanical properties. PHBV blending with poly(lactide-co-glycolide) (PLGA) is also explored to increase the processing properties of the polymeric mixture used for composite scaffold fabrication. Different HA percentages, up to 15% wt., can be loaded into the PHBV or PHBV/PLGA scaffolds without compromising their interconnected porous architecture, as well as the polymer morphological and thermal properties, as demonstrated by scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. In addition, HA loading results in increased scaffold compressive stiffness to levels comparable to those of trabecular bone tissue, as well as in higher in vitro MC3T3-E1 cell viability and production of mineralized extracellular matrix, in comparison to what observed for unloaded scaffolds. The observed mechanical and biological properties suggest the suitability of the developed scaffolds for bone engineering.
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