成纤维细胞活化蛋白
肿瘤微环境
免疫抑制
CD8型
癌症
癌症研究
医学
癌相关成纤维细胞
免疫疗法
靶向治疗
肿瘤进展
肿瘤浸润淋巴细胞
免疫系统
免疫学
内科学
肿瘤细胞
作者
Masaaki Akai,Kazuhiro Noma,Takuya Kato,Seitaro Nishimura,Hijiri Matsumoto,Ken Kawasaki,Tomoyoshi Kunitomo,Teruki Kobayashi,Noriyuki Nishiwaki,Hajime Kashima,Shinichi Kikuchi,Toshiaki Ohara,Hiroshi Tazawa,Peter L. Choyke,Hisataka Kobayashi,Toshiyoshi Fujiwara
标识
DOI:10.1038/s41416-024-02639-1
摘要
Abstract Background Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a critical role in tumor immunosuppression. However, targeted depletion of CAFs is difficult due to their diverse cells of origin and the resulting lack of specific surface markers. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that leads to rapid cell membrane damage. Methods In this study, we used anti-mouse fibroblast activation protein (FAP) antibody to target FAP + CAFs (FAP-targeted NIR-PIT) and investigated whether this therapy could suppress tumor progression and improve tumor immunity. Results FAP-targeted NIR-PIT induced specific cell death in CAFs without damaging adjacent normal cells. Furthermore, FAP-targeted NIR-PIT treated mice showed significant tumor regression in the CAF-rich tumor model accompanied by an increase in CD8 + tumor infiltrating lymphocytes (TILs). Moreover, treated tumors showed increased levels of IFN-γ, TNF-α, and IL-2 in CD8 + TILs compared with non-treated tumors, suggesting enhanced antitumor immunity. Conclusions Cancers with FAP-positive CAFs in their TME grow rapidly and FAP-targeted NIR-PIT not only suppresses their growth but improves tumor immunosuppression. Thus, FAP-targeted NIR-PIT is a potential therapeutic strategy for selectively targeting the TME of CAF + tumors.
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