Symptomatic androgen deficiency and sexual dysfunctions in male patients receiving alectinib for ALK‐positive advanced nonsmall cell lung cancer

医学 阿列克替尼 队列 内科学 肺癌 雄激素 睾酮(贴片) 胃肠病学 癌症 间变性淋巴瘤激酶 肿瘤科 激素 恶性胸腔积液
作者
Emanuele Vita,Federico Monaca,Domenico Milardi,Luca Mastrantoni,Alessio Stefani,Edoardo Vergani,Jacopo Russo,D. Barone,Ileana Sparagna,A. Vitale,Alessandro Scala,Denis Occhipinti,Mariantonietta Di Salvatore,Alfredo Pontecorvi,Giampaolo Tortora,Emilio Bria
出处
期刊:Cancer [Wiley]
卷期号:130 (15): 2611-2620
标识
DOI:10.1002/cncr.35293
摘要

ABSTRACT Background It is reported that treatment with anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) induces hypogonadism both in male patients with ALK‐positive cancer and in murine models. Methods In this study, three groups, including an experimental group of male patients with ALK‐positive, advanced non–small cell lung cancer (ANSCLC) who were receiving alectinib (cohort A), a control group of female patients with ALK‐positive ANSCLC who were receiving alectinib (cohort B), and a control group of male patients with ALK‐negative ANSCLC (cohort C), prospectively underwent a full hormone assessment for androgen deficiency at 8 weeks after the start of treatment and in case of reported suspected symptoms. Patients with major sexual dysfunctions were referred to an endocrinologist. Results Ninety‐five patients were consecutively enrolled onto the study. Among sixty‐eight male patients, both median total testosterone levels (2.93 vs. 4.92 ng/ml; p = .0001) and free testosterone levels (0.11 vs. 0.17 pg/ml; p = .0002) were significantly lower in ALK‐positive ANSCLC patients in cohort A compared with ALK‐negative patients in cohort C; conversely, median FSH (10.32 vs. 17.52 mUI/ml; p = .0059) and LH levels (4.72 vs. 7.49 mUI/ml; p = .0131) were significantly higher in cohort C compared to cohort A. Median inhibin B levels were higher in ALK‐positive male patients (74.3 vs. 44.24 pg/ml; p = .0038), but all patients had inhibin B values within the normal range. The percentage of male patients who had positive scores on the Androgen Deficiency in Aging Males (ADAM) questionnaire was 62% in cohort A and 26.8% in cohort C, including eight patients who reported at least one major symptom and were referred to Andrology Unit. No significant differences in the endocrine assessment were reported between cohorts A and B. Conclusions Symptoms of androgen deficiency should be tracked in male patients with ALK‐positive ANSCLC who are receiving alectinib, and testosterone replacement should be considered, as appropriate.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
H哈哈完成签到,获得积分10
1秒前
1秒前
2秒前
yggggg发布了新的文献求助10
2秒前
djiwisksk66应助Billy采纳,获得10
3秒前
3秒前
大个应助一蓑烟雨任平生采纳,获得10
3秒前
4秒前
务实静槐完成签到,获得积分10
4秒前
传奇3应助茶烟梧月采纳,获得30
4秒前
4秒前
4秒前
lalala发布了新的文献求助10
5秒前
Walter发布了新的文献求助10
5秒前
5秒前
爆米花应助yggggg采纳,获得10
6秒前
7秒前
7秒前
7秒前
7秒前
8秒前
量子星尘发布了新的文献求助10
9秒前
俎树同发布了新的文献求助10
10秒前
10秒前
无聊的寒烟完成签到,获得积分10
11秒前
小马甲应助欢呼涑采纳,获得10
11秒前
orixero应助Cici采纳,获得10
11秒前
NexusExplorer应助机智思真采纳,获得10
11秒前
11秒前
12秒前
12秒前
season发布了新的文献求助10
12秒前
YY完成签到,获得积分0
12秒前
12秒前
木子秀完成签到,获得积分10
12秒前
Mine发布了新的文献求助10
13秒前
积雪信完成签到 ,获得积分10
13秒前
14秒前
14秒前
风趣的泥猴桃完成签到 ,获得积分20
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970632
求助须知:如何正确求助?哪些是违规求助? 3515261
关于积分的说明 11177794
捐赠科研通 3250448
什么是DOI,文献DOI怎么找? 1795314
邀请新用户注册赠送积分活动 875781
科研通“疑难数据库(出版商)”最低求助积分说明 805073