Synthesis of bioengineered heparin chemically and biologically similar to porcine-derived products and convertible to low MW heparin
肝素
化学
抗凝剂
药理学
生物化学
医学
外科
作者
Marc Douaisi,Elena E. Paskaleva,Li Fu,Navdeep Grover,Charity McManaman,Sony Varghese,Paul R. Brodfuehrer,James M. Gibson,Ian de Joode,Ke Xia,Matthew Brier,Trevor J. Simmons,Payel Datta,Fuming Zhang,Akihiro Onishi,Makoto Hirakane,Daisuke Mori,Robert J. Linhardt,Jonathan S. Dordick
-sulfo levels similar to those of porcine heparins. We also report the conversion of our bioengineered heparin into a LMWH that is biologically and compositionally similar to USP enoxaparin. Ultimately, we demonstrate major advances to a process to provide a potential clinical and sustainable alternative to porcine-derived heparin products.