RAR-alpha: Creator, protector, and tormentor

Retinoic acid receptors are important for homeostatic synaptic plasticity and have many beneficial effects within the brain. New work by Cao et al. 1 Cao B. Scherrer G. Chen L. Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain. Neuron. 2022; https://doi.org/10.1016/j.neuron.2022.09.027 Abstract Full Text Full Text PDF Scopus (4) Google Scholar uncovers a role for these receptors in driving neuropathic pain development, thus identifying a potential preventative therapeutic target. Retinoic acid receptors are important for homeostatic synaptic plasticity and have many beneficial effects within the brain. New work by Cao et al. 1 Cao B. Scherrer G. Chen L. Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain. Neuron. 2022; https://doi.org/10.1016/j.neuron.2022.09.027 Abstract Full Text Full Text PDF Scopus (4) Google Scholar uncovers a role for these receptors in driving neuropathic pain development, thus identifying a potential preventative therapeutic target. Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic painCao et al.NeuronOctober 11, 2022In BriefRetinoic acid receptor signaling is critically involved in homeostatic synaptic plasticity in many brain circuits. In this study, Cao et al. demonstrated that RARα in spinal cord dorsal horn PV+ neurons is a key mediator for spared-nerve-injury-induced homeostatic changes that lead to central sensitization and neuropathic pain. Full-Text PDF