Genome‐wide DNA methylation analysis of body composition in Chinese monozygotic twins

DNA甲基化 表观遗传学 甲基化 生物 差异甲基化区 CpG站点 遗传学 基因 混淆 基因表达 内科学 医学
作者
Huimin Tian,Hong Qiao,Fulei Han,Xiangjie Kong,Shuai Zhu,Fangjie Xing,Haiping Duan,Weilong Li,Weijing Wang,Dongfeng Zhang,Yili Wu
出处
期刊:European Journal of Clinical Investigation [Wiley]
卷期号:53 (11) 被引量:2
标识
DOI:10.1111/eci.14055
摘要

Little is currently known about epigenetic alterations associated with body composition in obesity. Thus, we aimed to explore epigenetic relationships between genome-wide DNA methylation levels and three common traits of body composition as measured by body fat percentage (BF%), fat mass (FM) and lean body mass (LBM) among Chinese monozygotic twins.Generalized estimated equation model was used to regress the methylation level of CpG sites on body composition. Inference about Causation Through Examination Of Familial Confounding was used to explore the evidence of a causal relationship. Gene expression analysis was further performed to validate the results of differentially methylated genes.We identified 32, 22 and 28 differentially methylated CpG sites (p < 10-5 ) as well as 20, 17 and eight differentially methylated regions (slk-corrected p < 0.05) significantly associated with BF%, FM and LBM which were annotated to 65 genes, showing partially overlapping. Causal inference demonstrated bidirectional causality between DNA methylation and body composition (p < 0.05). Gene expression analysis revealed significant correlations between expression levels of five differentially methylated genes and body composition (p < 0.05).These DNA methylation signatures will contribute to increased knowledge about the epigenetic basis of body composition and provide new strategies for early prevention and treatment of obesity and its related diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
夕拾发布了新的文献求助10
刚刚
Owen应助聪慧小霜采纳,获得10
1秒前
Hello应助聪慧小霜采纳,获得10
1秒前
思源应助聪慧小霜采纳,获得10
1秒前
所所应助聪慧小霜采纳,获得10
1秒前
Lucas应助聪慧小霜采纳,获得10
1秒前
言亦云应助聪慧小霜采纳,获得30
1秒前
2秒前
所所应助yuyu采纳,获得10
4秒前
云海老完成签到,获得积分10
5秒前
jimskylxk完成签到,获得积分10
5秒前
Joker完成签到,获得积分20
5秒前
研友_VZG7GZ应助聪慧小霜采纳,获得10
6秒前
ding应助聪慧小霜采纳,获得10
7秒前
情怀应助聪慧小霜采纳,获得30
7秒前
可爱的函函应助聪慧小霜采纳,获得10
7秒前
7秒前
酷波er应助聪慧小霜采纳,获得10
7秒前
无花果应助聪慧小霜采纳,获得30
7秒前
丘比特应助聪慧小霜采纳,获得10
7秒前
乐乐应助聪慧小霜采纳,获得10
7秒前
善学以致用应助聪慧小霜采纳,获得10
7秒前
Jasper应助聪慧小霜采纳,获得30
7秒前
U2完成签到,获得积分10
8秒前
8秒前
smottom应助puzhongjiMiQ采纳,获得10
9秒前
天天快乐应助puzhongjiMiQ采纳,获得10
9秒前
王鹏飞应助puzhongjiMiQ采纳,获得10
9秒前
JamesPei应助puzhongjiMiQ采纳,获得10
9秒前
万能图书馆应助puzhongjiMiQ采纳,获得10
9秒前
王鹏飞应助puzhongjiMiQ采纳,获得10
9秒前
王鹏飞应助puzhongjiMiQ采纳,获得10
9秒前
张童鞋完成签到 ,获得积分10
10秒前
10秒前
Albertxkcj发布了新的文献求助10
12秒前
Jero完成签到 ,获得积分10
12秒前
程程程发布了新的文献求助10
12秒前
KKKKKKK完成签到 ,获得积分10
15秒前
北譩完成签到,获得积分10
17秒前
共享精神应助聪慧小霜采纳,获得10
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969557
求助须知:如何正确求助?哪些是违规求助? 3514377
关于积分的说明 11173836
捐赠科研通 3249692
什么是DOI,文献DOI怎么找? 1794979
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804836