先天性淋巴细胞
生物
细胞生物学
免疫学
免疫
淋巴细胞生成
平衡
先天免疫系统
免疫系统
干细胞
造血
作者
Xin Shen,Xianzhi Gao,Yikai Luo,Qianying Xu,Ying Fan,Shenghui Hong,Zhengwei Huang,Xiaoqian Liu,Qianqian Wang,Zuojia Chen,Di Wang,Linrong Lu,Chuan Wu,Han Liang,Lie Wang
出处
期刊:Nature Aging
日期:2023-07-10
卷期号:3 (8): 965-981
被引量:22
标识
DOI:10.1038/s43587-023-00453-7
摘要
Taken together, our findings highlight the influence of Cxxc1-maintained H3K4me3 on innate lymphocyte homeostasis and function during aging, and suggest that targeting intestinal ILC3 may pave the way for novel strategies to improve the fight against age-related infections. To our knowledge, this is the first report revealing the biological effects of Cxxc1-dependent H3K4me3 in aged gut ILC3s
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