鼻咽癌
免疫系统
免疫疗法
机制(生物学)
肿瘤微环境
恶性肿瘤
免疫学
免疫逃逸
癌变
生物
癌症研究
发病机制
爱泼斯坦-巴尔病毒
转移
病毒
医学
癌症
放射治疗
内科学
遗传学
哲学
认识论
作者
Xiaoxu Li,Yilin Guo,Minmin Xiao,Wenling Zhang
标识
DOI:10.1096/fj.202201628rr
摘要
Abstract Tumor cells are known for being able to evade immune system surveillance, a hallmark of malignancy. Complicated immune escape mechanisms in the tumor microenvironment (TME) provide favorable conditions for tumor invasion, metastasis, treatment resistance, and recurrence. Epstein–Barr virus (EBV) infection is closely related to the pathogenesis of nasopharyngeal carcinoma (NPC), and the co‐existence of EBV‐infected NPC cells and tumor‐infiltrating lymphocytes represents a distinctive, highly heterogeneous, and suppressive TME that supports immune escape and promotes tumorigenesis. Understanding the complex interaction between EBV and NPC host cells and focusing on the immune escape mechanism of TME may help to identify specific immunotherapy targets and to develop effective immunotherapy drugs.
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