壳聚糖
伤口愈合
伤口敷料
表面改性
材料科学
伤口护理
纳米技术
生物医学工程
化学
医学
外科
复合材料
有机化学
物理化学
作者
Deepak Verma,Manunya Okhawilai,Kheng Lim Goh,Vijay Kumar Thakur,Senthilkumar Nangan,Mohit Sharma,Hiroshi Uyama
标识
DOI:10.1016/j.envres.2023.116580
摘要
Functionalized chitosan nanocomposites have been studied for wound dressing applications due to their excellent antibacterial and anti-fungal properties. Polysaccharides show excellent antibacterial and drug-release properties and can be utilized for wound healing. In this article, we comprise distinct approaches for chitosan functionalization, such as photosensitizers, dendrimers, graft copolymerization, quaternization, acylation, carboxyalkylation, phosphorylation, sulfation, and thiolation. The current review article has also discussed brief insights on chitosan nanoparticle processing for biomedical applications, including wound dressings. The chitosan nanoparticle preparation technologies have been discussed, focusing on wound dressings owing to their targeted and controlled drug release behavior. The future directions of chitosan research include; a) finding an effective solution for chronic wounds, which are unable to heal completely; b) providing effective wound healing solutions for diabetic wounds and venous leg ulcers; c) to better understanding the wound healing mechanism with such materials which can help provide the optimum solution for wound dressing; d) to provide an improved treatment option for wound healing.
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