微生态学
发病机制
炎症性肠病
结直肠癌
免疫系统
免疫学
大肠癌小鼠模型的建立
炎症
医学
结肠炎
微卫星不稳定性
癌症
染色体不稳定性
疾病
癌症研究
生物
遗传学
病理
内科学
等位基因
基因
染色体
微卫星
生态学
作者
Yue Yin,Jian Wan,Jingmin Yu,Kaichun Wu
出处
期刊:Inflammatory Bowel Diseases
[Oxford University Press]
日期:2023-05-18
卷期号:29 (10): 1648-1657
被引量:3
摘要
Patients with inflammatory bowel disease (IBD) have a high risk for colorectal cancer (CRC). This cancer type, which is strongly associated with chronic inflammation, is called colitis-associated CRC (CAC). Understanding the molecular pathogenesis of CAC is crucial to identify biomarkers necessary for early diagnosis and more effective treatment directions. The accumulation of immune cells and inflammatory factors, which constitute a complex chronic inflammatory environment in the intestinal mucosa, may cause oxidative stress or DNA damage to the epithelial cells, leading to CAC development and progression. An important feature of CAC is genetic instability, which includes chromosome instability, microsatellite instability, hypermethylation, and changes in noncoding RNAs. Furthermore, the intestinal microbiota and metabolites have a great impact on IBD and CAC. By clarifying immune, genetic, intestinal microecology, and other related pathogenesis, CAC may be more predictable and treatable.This review summarizes the molecular pathogenesis of colitis-associated colorectal cancer (CAC) from the aspects of immunity, genetics, and intestinal microecology, and it points out the potential mechanisms worthy of further study. It highlights the complexity of the inflammation process to cancer and the dual effects of inflammatory mediators in order to provide inspiration for finding effective biomarkers or targets to make CAC more predictable and treatable.
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