GTP酶
Ras超家族
细胞生物学
化学
GTP结合蛋白调节剂
鸟苷
鸟嘌呤核苷酸交换因子
信号转导
GTP'
生物
G蛋白
生物化学
酶
作者
Yijing Zhang,Guanyi Li,Yulan Zhao
标识
DOI:10.1016/j.bmc.2023.117337
摘要
Rho guanosine triphosphatases (Rho GTPases), as members of the Ras superfamily, are GDP/GTP binding proteins that behave as molecular switches for the transduction of signals from external stimuli. Rho GTPases play essential roles in a number of cellular processes including cell cycle, cell polarity as well as cell migration. The dysregulations of Rho GTPases are related with various diseases, especially with cancers. Accumulating evidence supports that Rho GTPases play important roles in cancer development and progression. Rho GTPases become potential therapeutic targets for cancer therapy. And a number of inhibitors targeting Rho GTPases have been developed. In this review, we discuss their structural features, summarize their roles in cancer, and focus on the recent progress of their inhibitors, which are beneficial for the drug discovery targeting Rho GTPases.
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