Review on effects of some insecticides on honey bee health

Insecticides, one of the main agrochemicals, are useful for controlling pests; however, the indiscriminate use of insecticides has led to negative effects on nontarget insects, especially honey bees, which are essential for pollination services. Different classes of insecticides, such as neonicotinoids, pyrethroids, chlorantraniliprole, spinosad, flupyradifurone and sulfoxaflor, not only negatively affect honey bee growth and development but also decrease their foraging activity and pollination services by influencing their olfactory sensation, memory, navigation back to the nest, flight ability, and dance circuits. Honey bees resist the harmful effects of insecticides by coordinating the expression of genes related to immunity, metabolism, and detoxification pathways. To our knowledge, more research has been conducted on the effects of neonicotinoids on honey bee health than those of other insecticides. In this review, we summarize the current knowledge regarding the effects of some insecticides, especially neonicotinoids, on honey bee health. Possible strategies to increase the positive impacts of insecticides on agriculture and reduce their negative effects on honey bees are also discussed.