强直性脊柱炎
发病机制
病理生理学
HLA-B27
脊柱炎
医学
免疫学
强直
骶髂关节炎
脊椎关节病
生物信息学
生物
人类白细胞抗原
病理
抗原
牙科
出处
期刊:IntechOpen eBooks
[IntechOpen]
日期:2023-01-20
被引量:4
标识
DOI:10.5772/intechopen.109164
摘要
The pathogenesis and pathophysiology of Ankylosing Spondylitis (AS) is complex and remains only partially understood. Contributory genes including a variety of HLA-B27 subset genes and many other non-HLA genes are implicated in the literature. Novel genes and gene–gene interactions being a continuously evolving area of AS research. Dysregulation of the enteric microbiome with a corresponding aberrant immunological response is recognised in research. Certain infectious agents are thought to play a role. A variety of other influences including environmental exposures, dietary and lifestyle factors and sex hormones appear to play a role in AS pathogenesis. There is emerging evidence that that pathophysiological response in AS is an elaborate combination of both autoinflammatory and autoimmune components, however the IL-17/IL-23 pathway remains the major pathway in AS according to studies to date. The specific mechanisms that lead to characteristic clinical features of AS including sacroiliitis, spondylitis, ankylosis, uveitis and other extra articular manifestations remain occult. Further research to establish these is ongoing.
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