Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study

孟德尔随机化 医学 置信区间 内科学 多效性 骨矿物 单核苷酸多态性 骨质疏松症 全基因组关联研究 缬氨酸
作者
Zhiyong Cui,Hui Feng,Baichuan He,Jinyao He,Yun Tian
出处
期刊:Frontiers in Endocrinology [Frontiers Media]
卷期号:12
标识
DOI:10.3389/fendo.2021.763538
摘要

Background This study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD). Methods We performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods. Results Our study found that genetically increased isoleucine (Ile) [IVW: effect = 0.1601, 95% confidence interval (CI) = 0.0604 ~ 0.2597, p = 0.0016] and valine (Val) levels (IVW: effect = 0.0953, 95% CI = 0.0251 ~ 0.1655, p = 0.0078) were positively associated with total body BMD (TB-BMD). The results also revealed that genetically increased tyrosine (Tyr) levels were negatively associated with TB-BMD (IVW: effect = -0.1091, 95% CI = -0.1863 ~ -0.0320, p = 0.0055). Conclusions In this study, associations between serum AA levels and BMD were established. These findings underscore the important role that serum AAs play in the development of osteoporosis and provide evidence that osteoporosis can be prevented and treated by the intake of certain AAs.

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