MDA5型
RNA沉默
干扰素
核糖核酸
病毒学
生物
突变体
RNA干扰
遗传学
基因
作者
Liam P. Keegan,Dragana Vukić,Mary A. O’Connell
标识
DOI:10.1016/j.it.2021.09.013
摘要
ADAR1 edits adenosines to inosines in cellular double-stranded (ds)RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutières syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al., Maurano et al., and de Reuver et al. demonstrated that Adar1 Zα domain-mutant mice show aberrant MDA5 and PKR activation, developing encephalopathies; short Z-RNA patches within cellular dsRNA are unexpectedly crucial in causing aberrant antiviral responses.
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