Solid Organ Transplantation

Please add expansion for AL. Hematologic disease control combined with solid organ transplantation can result in long-term survival in selected patients with light chain (AL) amyloidosis and limited other organ involvement. Restoration of critical cardiac function with organ transplantation can render patients eligible for effective disease-directed therapies, including high-dose therapy and autologous stem cell transplantation . Access to directed-donor organs, exchange programs for renal transplantation , and extended-donor organs for cardiac transplantation improves the availability of organs for patients with AL amyloidosis . Disease recurrence in the graft and progression in other organs remain concerns but often can be managed with a variety of effective plasma cell–directed therapies.