视黄醇
获得性免疫系统
维甲酸
维生素
LRP1型
低密度脂蛋白受体
化学
免疫系统
细胞生物学
髓样
生物
免疫学
免疫
生物化学
脂蛋白
胆固醇
基因
作者
Ye-Ji Bang,Zehan Hu,Yun Li,Sureka Gattu,Kelly A. Ruhn,Prithvi Raj,Joachim Herz,Lora V. Hooper
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-09-16
卷期号:373 (6561)
被引量:53
标识
DOI:10.1126/science.abf9232
摘要
SAAving vitamin A–mediated immunity The vitamin A metabolite retinol is critical for B and T cell development and homing to the gut. Intestinal myeloid cells such as dendritic cells and macrophages take up retinol and process it into retinoic acid (RA), which in turn initiates RA-dependent gene expression programs in lymphocytes. Bang et al . identified LDL receptor-related protein 1 (LRP1) as a myeloid cell surface receptor for retinol. LRP1 binds retinol chaperoned by serum amyloid A (SAA) proteins, and SAA–retinol complexes are then endocytosed and metabolized by myeloid cells. Mice lacking either Saa or myeloid-specific Lrp1 exhibited profound impairments in vitamin A–mediated immunity. B and T cell trafficking to the intestine, immunoglobulin A production by B cells, and protection from enteric Salmonella Typhimurium infection were all diminished when either of these crucial players was missing. —STS
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