胶质瘤
听觉皮层
神经科学
皮质(解剖学)
心理学
医学
癌症研究
作者
Alexander A. Aabedi,Benjamin Lipkin,Jasleen Kaur,Sofia Kakaizada,Claudia Valdivia,Sheantel Reihl,Jacob S. Young,Anthony T. Lee,Saritha Krishna,Mitchel S. Berger,Edward F. Chang,David Brang,Shawn L. Hervey‐Jumper
标识
DOI:10.1073/pnas.2108959118
摘要
Significance As gliomas proliferate, they infiltrate healthy brain tissue. Often, patients with such tumors in the language areas of the brain develop aphasia. Understanding how gliomas interact with normal neural circuits is critical for developing neuroprostheses that restore speech. Recent evidence demonstrates that glioma cells interact synaptically with neurons and thus can modulate neural circuits. However, it is unclear the extent to which glioma-infiltrated cortex participates in cognitive processing. Using electrocorticography to record both glioma-infiltrated and normal-appearing cortex during speech, we found that glioma-infiltrated cortex is capable of coordinated neural responses but has reduced capacity for information encoding. Instead, glioma-infiltrated cortex recruits a broader network of cortical regions during speech, which may represent a compensatory mechanism with implications for future neuroprostheses.
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