Frequency and phenotypical alterations of unconventional T cells in cystic fibrosis

囊性纤维化 医学 流式细胞术 炎症 免疫学 表型 纤维化 T细胞 内科学 免疫系统 生物 生物化学 基因
作者
Pauline Tossan,Sylvie Legué,L.M. González,Thomas Flament,Julie Mankikian,Youen Jouan,Antoine Guillon,Mustapha Si‐Tahar,Christophe Paget
标识
DOI:10.1183/13993003.congress-2021.oa1497
摘要

Introduction: Cystic fibrosis (CF) is characterized by a sustained and persistent inflammation within the lungs. Unconventional T lymphocytes, a heterogeneous class of T lymphocytes (e.g. MAIT, γδT, and iNKT cells) play a key role in orchestrating the inflammatory response at mucosal sites and participate in the fine-tuning of the host inflammatory response. Aims and objectives: To evaluate the frequency and state of activation of unconventional T lymphocytes in adult patients with CF. We hypothesized that unconventional T cell response could be dysregulated and contribute to the chronic inflammation observed in CF. Methods: We conducted a prospective study by enrolling 62 patients from the Cystic Fibrosis Center of Tours, France, between April 2019 and October 2020. MAIT, γδT, and iNKT cells were measured in patient’s blood as compared to 49 healthy controls. Activation status was assessed by monitoring CD-69 and PD-1 markers by flow cytometry. Results: In comparison to healthy controls, γδT cells were significantly increased in the peripheral blood of CF patients (9.2 % vs 3.6 % of T-lymphocytes, p < 0.001), whereas MAIT and iNKT proportions were decreased (respectively 1.4 % vs 2.6%, p < 0.01 and 0.04 % vs 0.1 %, p< 0.001). All unconventional T cell subsets displayed an activated phenotype in patients with CF compared to healthy controls. Conclusion: The relative proportion of all circulating unconventional T cell subsets differs significantly in CF patients as compared to healthy controls. In addition, these subsets display a highly activated phenotype. Altogether, this supports the hypothesis that unconventional T cells play a role in the regulation of the inflammatory response during CF.

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