Toward more accurate prediction of future pregnancy outcome in couples with unexplained recurrent pregnancy loss: taking both partners into account

怀孕 结果(博弈论) 医学 产科 妇科 经济 生物 遗传学 数理经济学
作者
Nadia A. du Fossé,Marie‐Louise van der Hoorn,Rozemarijn de Koning,A. Mulders,J. M. M. van Lith,Saskia le Cessie,E.E.L.O. Lashley
出处
期刊:Fertility and Sterility [Elsevier BV]
卷期号:117 (1): 144-152 被引量:20
标识
DOI:10.1016/j.fertnstert.2021.08.037
摘要

ObjectiveTo identify, besides maternal age and the number of previous pregnancy losses, additional characteristics of couples with unexplained recurrent pregnancy loss (RPL) that improve the prediction of an ongoing pregnancy.DesignHospital-based cohort study in couples who visited specialized RPL units of two academic centers between 2012 and 2020.SettingTwo academic centers in the Netherlands.PatientsClinical data from 526 couples with unexplained RPL were used in this study.Intervention(s)None.Main Outcome MeasuresThe final model to estimate the chance of a subsequent ongoing pregnancy was determined using a backward selection process and internally validated using bootstrapping. Model performance was assessed in terms of calibration and discrimination (area under the receiver operating characteristic curve).ResultsSubsequent ongoing pregnancy was achieved in 345 of 526 couples (66%). The number of previous pregnancy losses, maternal age, paternal age, maternal body mass index, paternal body mass index, maternal smoking status, and previous in vitro fertilization/intracytoplasmic sperm injection treatment were predictive of the outcome. The optimism-corrected area under the receiver operating characteristic curve was 0.63 compared with 0.57 when using only the number of previous pregnancy losses and maternal age.ConclusionsThe identification of additional predictors of a subsequent ongoing pregnancy after RPL, including male characteristics, is significant for both clinicians and couples with RPL. At the same time, we showed that the predictive ability of the current model is still limited and more research is warranted to develop a model that can be used in clinical practice. To identify, besides maternal age and the number of previous pregnancy losses, additional characteristics of couples with unexplained recurrent pregnancy loss (RPL) that improve the prediction of an ongoing pregnancy. Hospital-based cohort study in couples who visited specialized RPL units of two academic centers between 2012 and 2020. Two academic centers in the Netherlands. Clinical data from 526 couples with unexplained RPL were used in this study. None. The final model to estimate the chance of a subsequent ongoing pregnancy was determined using a backward selection process and internally validated using bootstrapping. Model performance was assessed in terms of calibration and discrimination (area under the receiver operating characteristic curve). Subsequent ongoing pregnancy was achieved in 345 of 526 couples (66%). The number of previous pregnancy losses, maternal age, paternal age, maternal body mass index, paternal body mass index, maternal smoking status, and previous in vitro fertilization/intracytoplasmic sperm injection treatment were predictive of the outcome. The optimism-corrected area under the receiver operating characteristic curve was 0.63 compared with 0.57 when using only the number of previous pregnancy losses and maternal age. The identification of additional predictors of a subsequent ongoing pregnancy after RPL, including male characteristics, is significant for both clinicians and couples with RPL. At the same time, we showed that the predictive ability of the current model is still limited and more research is warranted to develop a model that can be used in clinical practice.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
chenfeng发布了新的文献求助30
刚刚
parrowxg完成签到,获得积分10
1秒前
2秒前
orixero应助夏xx采纳,获得10
2秒前
盼盼527完成签到,获得积分10
3秒前
nissy完成签到,获得积分10
4秒前
11发布了新的文献求助10
5秒前
刺五加发布了新的文献求助10
5秒前
5秒前
6秒前
6秒前
OOYWZEHNN发布了新的文献求助10
7秒前
bq完成签到,获得积分10
8秒前
AJoe发布了新的文献求助50
10秒前
库库写论文完成签到,获得积分10
11秒前
空写乐发布了新的文献求助30
12秒前
双生客完成签到,获得积分10
13秒前
OOYWZEHNN完成签到,获得积分10
14秒前
16秒前
量子星尘发布了新的文献求助50
17秒前
18秒前
领导范儿应助AJoe采纳,获得10
19秒前
nissy发布了新的文献求助20
19秒前
科研通AI6应助幽默的宛白采纳,获得10
21秒前
21秒前
夏xx发布了新的文献求助10
22秒前
Lucas应助天真的迎天采纳,获得10
22秒前
orixero应助甜甜亦丝采纳,获得10
23秒前
23秒前
24秒前
鸣谦发布了新的文献求助20
25秒前
CQY发布了新的文献求助10
25秒前
percy完成签到 ,获得积分10
25秒前
马凤智完成签到 ,获得积分10
26秒前
九月亦星完成签到 ,获得积分10
26秒前
zhangyu3230发布了新的文献求助10
27秒前
27秒前
谢挽风发布了新的文献求助10
28秒前
尼亚吉拉发布了新的文献求助10
28秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Encyclopedia of Materials: Plastics and Polymers 1000
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
Hidden Generalizations Phonological Opacity in Optimality Theory 1000
Handbook of Social and Emotional Learning, Second Edition 900
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4920461
求助须知:如何正确求助?哪些是违规求助? 4192039
关于积分的说明 13020047
捐赠科研通 3962876
什么是DOI,文献DOI怎么找? 2172323
邀请新用户注册赠送积分活动 1190156
关于科研通互助平台的介绍 1098997