纳米复合材料
光热治疗
伤口愈合
抗菌活性
活性氧
二硫化钼
纳米技术
抗氧化剂
氧化应激
材料科学
医学
化学
复合材料
有机化学
外科
细菌
生物
生物化学
遗传学
作者
Tengfei Ma,Xinyun Zhai,Yongkang Huang,Mengzhen Zhang,Xiaoli Zhao,Yaping Du,Chun‐Hua Yan
标识
DOI:10.1002/adhm.202100033
摘要
Abstract Chronic wounds, such as the diabetic ulcer wounds have serious effect on people's lives, and can even lead to death. Diabetic ulcer wounds are different from normal wounds and much easier to be infected and induce oxidative stress due to the special surrounding microenvironment, which makes it necessary to prepare materials with antibacterial property and antioxidant activity simultaneously. The molybdenum disulfide‐ceria (MoS 2 ‐CeO 2 ) nanocomposite possesses both the photo‐thermal therapy (PTT) antibacterial capability of polyethylene glycol modified molybdenum disulfide nanosheets and the antioxidant activity of cerium dioxide nanoparticles (CeO 2 NPs). By combining the inherent antibacterial activity of CeO 2 NPs, the MoS 2 ‐CeO 2 nanocomposite exhibits excellent PTT antibacterial capability against both gram‐positive and gram‐negative bacteria through 808 nm laser treatment, thereby reducing the risk of wound infection. Owing to the abundant oxygen vacancies in CeO 2 NPs, Ce 3+ and Ce 4+ can transform reversibly which endows MoS 2 ‐CeO 2 nanocomposite with remarkable antioxidant ability to clear away the excessive reactive oxygen species around the diabetic ulcer wounds and promote wound healing. The results demonstrate that MoS 2 ‐CeO 2 nanocomposite is a promising class for the clinical treatment of chronic wounds especially the diabetic ulcer wounds, and 808 nm laser can be used as a PTT antibacterial switch.
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