Defining the functional divergence of orthologous genes between human and mouse in the context of miRNA regulation

基因 生物 背景(考古学) 计算生物学 分歧(语言学) 同源基因 表型 遗传学 基因组 古生物学 哲学 语言学
作者
Chunmei Cui,Yuan Zhou,Qinghua Cui
出处
期刊:Briefings in Bioinformatics [Oxford University Press]
卷期号:22 (6) 被引量:4
标识
DOI:10.1093/bib/bbab253
摘要

Animal models have a certain degree of similarity with human in genes and physiological processes, which leads them to be valuable tools for studying human diseases and for assisting drug development. However, translational researches adopting animal models are largely restricted by the species heterogeneity, which is also a major reason for the failure of drug research. Currently, computational method for exploring the functional differences between orthologous genes is still insufficient. For this purpose, here, we presented an algorithm, functional divergence score (FDS), by comprehensively evaluating the functional differences between the microRNAs regulating the paired orthologous genes. Given that mouse is one of the most popular model animals, currently, FDS was designed to dissect the functional divergence of orthologous genes between human and mouse. The results showed that gene FDS value is significantly associated with gene evolutionary characteristics and can discover expression divergence of human-mouse orthologous genes. Moreover, FDS performed well in distinguishing the targets of approved drugs and the failed ones. These results suggest that FDS is a valuable tool to evaluate the functional divergence of paired human and mouse orthologous genes. In addition, for each orthologous gene pair, FDS can provide detailed differences in functions and phenotypes. Our study provided a useful tool for quantifying the functional difference between human and mouse, and the presented framework is easily to be extended to the orthologous genes between human and other species. An online server of FDS is available at http://www.cuilab.cn/fds/.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
彪行天下完成签到,获得积分10
3秒前
danli完成签到 ,获得积分10
4秒前
guangyu完成签到,获得积分10
6秒前
学术老6完成签到,获得积分10
7秒前
c123完成签到 ,获得积分10
9秒前
恐怖稽器人完成签到,获得积分10
9秒前
WXR完成签到,获得积分10
10秒前
科研小白完成签到,获得积分10
10秒前
11秒前
可爱丸子完成签到,获得积分10
11秒前
皮汤汤完成签到 ,获得积分10
12秒前
JXDYYZK完成签到,获得积分10
13秒前
SYLH应助lu采纳,获得10
13秒前
Servant2023完成签到,获得积分10
13秒前
鸽子的迷信完成签到,获得积分10
15秒前
nine2652完成签到 ,获得积分10
16秒前
烂漫的睫毛完成签到 ,获得积分10
18秒前
量子星尘发布了新的文献求助10
18秒前
陈老太完成签到 ,获得积分10
19秒前
宇宇宇c完成签到,获得积分10
20秒前
zxt完成签到,获得积分10
21秒前
大橙子发布了新的文献求助10
24秒前
聪明静柏完成签到 ,获得积分10
26秒前
kimiwanano完成签到,获得积分10
28秒前
lu完成签到,获得积分10
29秒前
Profeto应助齐嫒琳采纳,获得10
30秒前
31秒前
情怀应助科研通管家采纳,获得10
32秒前
从来都不会放弃zr完成签到,获得积分10
36秒前
1459完成签到,获得积分10
38秒前
行者+完成签到,获得积分10
38秒前
GongSyi完成签到 ,获得积分10
39秒前
Boris完成签到 ,获得积分10
41秒前
哭泣笑柳完成签到,获得积分10
41秒前
万能图书馆应助大橙子采纳,获得10
44秒前
大眼睛土豆完成签到,获得积分10
48秒前
一条虫gg完成签到,获得积分10
51秒前
52秒前
53秒前
56秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022