自噬
虫草素
细胞生物学
衰老
安普克
PI3K/AKT/mTOR通路
溶酶体
细胞
mTORC1型
生物
化学
信号转导
磷酸化
蛋白激酶A
生物化学
酶
细胞凋亡
作者
Shi Zuo,Can Li,Yi Lun Liu,Yue Hao Tan,Xing Wan,Tian Xu,Qiang Li,Li Wang,Yong Wu,Feng Deng,Bin Tang
出处
期刊:FEBS Open Bio
[Wiley]
日期:2021-08-27
卷期号:11 (10): 2705-2714
被引量:9
标识
DOI:10.1002/2211-5463.13263
摘要
Cell senescence is closely related to autophagy. In this article, we identified a natural nucleoside analogue, cordycepin, that has the ability to significantly improve lysosomal function, enhance the activity of the lysosomal representative protease cathepsin B (CTSB), and promote the expression of the functional protein lysosomal-associated membrane protein 2 (LAMP2) on the lysosomal membrane. Cordycepin then restores the damaged autophagy level of aging cells by activating the classic AMPK and mTOR-p70S6K signaling pathways, thus inhibiting cell senescence in an H2 O2 -induced stress-induced premature senescence (SIPS) cell model. This study provides new theoretical support for the further development of cordycepin and clinical antiaging drugs to inhibit cell senescence and suggests that the regulatory mechanisms of lysosomes in senescent cells should be considered when treating age-related diseases.
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