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Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

医学 传统医学 减肥 芒果藤黄 安慰剂 荟萃分析 随机对照试验 植物疗法 不利影响 超重 替代医学 肥胖 内科学 病理
作者
Alison Maunder,Erica Bessell,Romy Lauche,Jon Adams,Amanda Sainsbury,Nicholas R. Fuller
出处
期刊:Diabetes, Obesity and Metabolism [Wiley]
卷期号:22 (6): 891-903 被引量:41
标识
DOI:10.1111/dom.13973
摘要

To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and meta-analysis of herbal medicines for weight loss.Four electronic databases (Medline, Embase, CINAHL and Web of Science) were searched from inception until August 2018. A total of 54 randomized placebo-controlled trials of healthy overweight or obese adults were identified. Meta-analyses were conducted for herbal medicines with ≥4 studies available. Weight differences of ≥2.5 kg were considered clinically significant.As a single agent, only Phaseolus vulgaris resulted in a statistically significant weight loss compared to placebo, although this was not considered clinically significant. No effect was seen for Camellia sinensis or Garcinia cambogia. Statistically, but not clinically, significant differences were observed for combination preparations containing C. sinensis, P. vulgaris or Ephedra sinica. Of the herbal medicines trialled in ≤3 randomized controlled trials, statistically and clinically significant weight loss compared to placebo was reported for Irvingia gabonensis, Cissus quadrangularis, and Sphaeranthus indicus combined with Garcinia mangostana, among others, but these findings should be interpreted cautiously because of the small number of studies, generally poor methodological quality, and poor reporting of the herbal medicine interventions. Most herbal medicines appeared safe for consumption over the short duration of the studies (commonly ≤12 weeks). Some warrant further investigation to determine effect size, dosage and long-term safety.There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review.
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