功能(生物学)
结构功能
结构生物学
蛋白质功能
蛋白质结构
细胞生物学
蛋白质家族
作者
Erich Bornberg-Bauer,Klára Hlouchová,Andreas Lange
标识
DOI:10.1016/j.sbi.2020.11.010
摘要
Comparative evolutionary genomics has revealed that novel protein coding genes can emerge randomly from non-coding DNA. While most of the myriad of transcripts which continuously emerge vanish rapidly, some attain regulatory regions, become translated and survive. More surprisingly, sequence properties of de novo proteins are almost indistinguishable from randomly obtained sequences, yet de novo proteins may gain functions and integrate into eukaryotic cellular networks quite easily. We here discuss current knowledge on de novo proteins, their structures, functions and evolution. Since the existence of de novo proteins seems at odds with decade-long attempts to construct proteins with novel structures and functions from scratch, we suggest that a better understanding of de novo protein evolution may fuel new strategies for protein design.
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