高价分子
化学
试剂
碘
有机化学
异氰酸酯
小学(天文学)
组合化学
药物化学
天文
物理
聚氨酯
作者
Xia Wang,Peng Yang,Bo Hu,Qian Zhang,Dong Li
标识
DOI:10.1021/acs.joc.0c02767
摘要
A novel transformation of primary amides to secondary amides promoted by hypervalent iodine reagents was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents.
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