Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide.

医学 来氟米特 骨质疏松症 类风湿性关节炎 股骨颈 内科学 骨矿物 双膦酸盐 优势比 危险系数 置信区间 外科
作者
Oh Chan Kwon,Ji Seon Oh,Seokchan Hong,Chang‐Keun Lee,Bin Yoo,Yong‐Gil Kim
出处
期刊:PubMed 卷期号:37 (5): 813-819 被引量:7
链接
标识
摘要

To investigate the effect of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis.Patients with RA who were newly diagnosed with osteoporosis (T-score ≤ -2.5) between 2010 and 2017 were included. All patients received background bisphosphonate for treatment of osteoporosis. BMD was measured at baseline and after one year. To identify csDMARDs or other factors associated with significant increase in BMD (≥3%) at lumbar spine and femoral neck at one year, we performed logistic regression analysis. To exclude the possibility of confounding by methotrexate, which was commonly used as a combination therapy with other csDMARDs, we also performed logistic regression analysis in the methotrexate users (subgroup analysis).In total, 153 RA patients with newly diagnosed osteoporosis were included. Leflunomide was the only csDMARD associated with significant increase in lumbar spine BMD (adjusted odds ratio (OR) 3.000, 95% confidence interval (CI) 1.177-7.645, p=0.021). In regard to femoral neck BMD, no csDMARDs were associated with significant increase in BMD. In the subgroup analysis, use of leflunomide was still associated with significant increase in lumbar spine BMD (adjusted OR 2.653, 95% CI 1.030-6.836, p=0.043), whereas no csDMARDs were associated with significant increase in femoral neck BMD.Among the csDMARDs, leflunomide can be beneficial in lumbar spine BMD in RA patients with osteoporosis.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
晚伍发布了新的文献求助10
4秒前
魏少爷发布了新的文献求助10
4秒前
4秒前
研友_xLOMQZ完成签到,获得积分0
5秒前
5秒前
de发布了新的文献求助10
5秒前
研友_8DAv0L发布了新的文献求助10
5秒前
天天快乐应助纯真采蓝采纳,获得10
6秒前
6秒前
6秒前
7秒前
Jasper应助稻下乘凉采纳,获得100
7秒前
柒月发布了新的文献求助10
8秒前
10秒前
tyf完成签到,获得积分10
10秒前
浮熙发布了新的文献求助10
10秒前
kykykkk完成签到,获得积分10
11秒前
redking发布了新的文献求助10
11秒前
比巴卜发布了新的文献求助10
13秒前
64658应助研友_8DAv0L采纳,获得10
14秒前
de完成签到,获得积分10
15秒前
天天快乐应助Endeavor采纳,获得10
16秒前
16秒前
18秒前
一只住在海边的猫完成签到,获得积分10
20秒前
21秒前
22秒前
wade发布了新的文献求助10
22秒前
纯真采蓝发布了新的文献求助10
24秒前
25秒前
25秒前
852应助高兴尔冬采纳,获得10
25秒前
zyq发布了新的文献求助10
26秒前
26秒前
奥暖将发布了新的文献求助10
27秒前
我是老大应助魏少爷采纳,获得10
27秒前
ZH完成签到,获得积分10
28秒前
搞怪初丹发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403