根皮苷
苹果属植物
蛋白激酶B
胰岛素抵抗
化学
胰岛素受体
福克斯O1
糖原合酶
生物化学
糖原
磷酸化
胰岛素
生物
葡萄糖转运蛋白
内分泌学
植物
作者
Dan Li,Yongli Yang,Lijun Sun,Zhongxiang Fang,Lei Chen,Pengtao Zhao,Zichao Wang,Yurong Guo
出处
期刊:Food bioscience
[Elsevier]
日期:2020-05-18
卷期号:36: 100637-100637
被引量:22
标识
DOI:10.1016/j.fbio.2020.100637
摘要
Insulin resistance (IR) has an important role in the development of type 2 diabetes (T2DM). This study aimed to investigate the effect of young apple (Malus domestica Borkh. cv. Red Fuji) polyphenols (YAP) on IR in HepG2 cells. It was found that YAP and its two main components, phlorizin and chlorogenic acid, could increase glucose uptake, glucose consumption and glycogen content. YAP and phlorizin activated the insulin receptor substrate 2/phosphatidylinositol 3-kinase/phosphorylation of the protein kinase B (IRS2/PI3K/AKT) signal pathway, as well as its downstream proteins glycogen synthase kinase-3β (GSK3β) and forkhead box protein O1 (FOXO1), which were further confirmed by application of the PI3K inhibitor LY294002. YAP and phlorizin also improved mitochondrial dysfunction by reducing mitochondrial reactive oxygen species (ROS) accumulation, restoring ATP production and the mitochondrial membrane potential (MMP). This study suggested that YAP has the potential to alleviate T2DM symptoms.
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