巴尔通体
钩端螺旋体
生物
钩端螺旋体病
遗传多样性
问号钩端螺旋体
病毒学
微生物学
兽医学
动物
人口
医学
环境卫生
作者
Qianqian Su,Yi Chen,Bo Wang,Chengmei Huang,Shuyi Han,Guohui Yuan,Qingxun Zhang,Hongxuan He
摘要
Abstract Commensal rats ( Rattus spp.), which are globally distributed, harbour many pathogens responsible for significant human diseases. Despite this, we have a poor understanding of the epidemiology and genetic diversity of some recently neglected zoonotic pathogens, such as Leptospira spp., Bartonella spp. and hepatitis E virus (HEV), which constitute a major public health threat. Thus, we surveyed the occurrences, co‐infection and genetic diversity of these pathogens in 129 urban rats from China. For Rattus tanezumi , the prevalences of Leptospira spp., Bartonella spp. and HEV infection were 6.67%, 0% and 46.67%, respectively. The prevalences of Leptospira spp., Bartonella spp. and HEV infection were 57.89%, 9.65% and 57.89% for Rattus norvegicus respectively. Leptospira spp. and HEV infections were more likely to occur in mature R. norvegicus . Phylogenetic analyses showed that pathogenic Leptospira interrogans and Leptospira borgpetersenii might exist. We also found that Bartonella spp. showed high similarity to Bartonella elizabethae , Bartonella rochalimae and Bartonella tribocorum , which are implicated in human disease. Dual and triple infections were both detected. Moreover, dual infections with Leptospira spp. and HEV represented the most frequent co‐infection, and there was a significantly positive association between them. High genetic diversity was observed in genes segments from Leptospira , Bartonella and HEV. Our results first discover the occurrence of multiple co‐infections and genetic diversity of Leptospira , Bartonella and HEV in commensal rats from China. Altogether, the present study provides an insight into evaluating the risk of rat‐borne zoonoses in urban China.
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