体内
四面体
DNA
化学
生物物理学
细胞生物学
纳米技术
计算生物学
生物化学
生物
材料科学
遗传学
结晶学
作者
Kyoung‐Ran Kim,Hyun Jegal,Jung-Hyun Kim,Dae‐Ro Ahn
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2020-01-01
卷期号:8 (2): 586-590
被引量:29
摘要
While siRNA is a potent therapeutic tool that can silence disease-causing mRNA, its in vivo potency can be compromised due to the lack of target tissue specificity. Here, we report a wireframe tetrahedral DNA nanostructure having a 20-mer duplex on each side that can be specifically distributed into the liver upon systemic administration. This liver-targeted DNA tetrahedron is employed as the carrier for liver-specific delivery of siRNA targeting ApoB1 mRNA, which is overexpressed in hypercholesterolemia. When delivered by a DNA tetrahedron, the siRNA can preferentially be accumulated in the liver and down-regulate the ApoB1 protein. As a result, the blood cholesterol level is also decreased by the siRNA. These results successfully demonstrate that the DNA tetrahedron is a promising carrier for liver-targeted delivery of therapeutic nucleic acids.
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