亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Helicobacter pylori eradication combined with folic acid in the treatment of chronic atrophic gastritis: a long-term follow-up study

医学 胃肠病学 内科学 幽门螺杆菌 萎缩性胃炎 B组 胃炎 快速尿素酶试验 叶酸 慢性胃炎
作者
刘庭玉,庄雅,lt,strong gt,党旖旎 lt,严谨,张国新
出处
期刊:Chinese Journal of Digestion 卷期号:36 (11): 734-739
标识
DOI:10.3760/cma.j.issn.0254-1432.2016.11.002
摘要

Objective To investigate the clinical and pathological outcome of gastric mucosa lesions in chronic atrophic gastritis treated with Helicobacter pylori (H.pylori) eradication combined with folic acid (three months treatments). Methods From December 2009 to December 2010, outpatients with chronic atrophic gastritis were selected and divided into H.pylori positive group and H.pylori negative group. The patients of H.pylori positive group were treated with standard triple H.pylori eradication therapy and then followed with folic acid; the patients of H.pylori negative group were only treated with folic acid. The treatment course of both groups was three months. H.pylori test and gastroscopy were carried out at 1st, 3rd and 5th year after treatment. According to the follow-up results, the patients were divided into H.pylori negative group, H.pylori successful eradication group and H.pylori reinfection group. Student′s t tests and Logistic regression were performed for statistical analysis. Results A total of 160 patients with chronic atrophic gastritis were included. There were 90 cases in H.pylori positive group and 70 cases in H.pylori negative group. There were 139 cases included after follow-up. There were 47 cases in H.pylori negative group, 63 cases in H.pylori successful eradication group, and 29 cases in H.pylori reinfection group. The gastric mucosal gastritis scores of H.pylori negative group significantly decreased at 1st, 3rd and 5th year after treatment (1.40±1.25, 1.54±0.61, and 1.63±0.94, respectively) compared with that before treatment (2.63±1.21), and the differences were statistically significant (t=4.073, 3.669 and 4.433, all P 0.05). The failure of H.pylori eradication(odds ratio (OR)=5.600, P=0.002) and H.pylori reinfection(OR=4.750, P=0.001)were both progression risk factors of chronic atrophic gastritis. Gender (female, OR=0.371), smoking (OR=3.357) and drinking (OR=3.368) were all risk factors of H.pylori reinfection (all P<0.05). Conclusion H.pylori eradiation combined with folic acid treatment can relieve mucosa inflammation in patients with chronic atrophic gastritis, improve atrophy and intestinal metaplasia. Key words: Chronic atrophic gastritis; Helicobacter pylori eradication; Folic acid; Follow-up studies
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
jwj发布了新的文献求助10
10秒前
沉静念真完成签到,获得积分10
27秒前
28秒前
30秒前
33秒前
35秒前
35秒前
自觉的小蝴蝶完成签到,获得积分10
37秒前
fairy112233完成签到,获得积分20
37秒前
菜鸡5号发布了新的文献求助10
38秒前
沉静念真发布了新的文献求助10
38秒前
醉了完成签到,获得积分10
40秒前
47秒前
HAG完成签到,获得积分10
54秒前
55秒前
思源应助科研通管家采纳,获得10
55秒前
爱静静应助科研通管家采纳,获得10
55秒前
爱静静应助科研通管家采纳,获得10
55秒前
顾矜应助沉静念真采纳,获得30
57秒前
蔓越莓蛋糕完成签到 ,获得积分10
1分钟前
端庄闭月完成签到,获得积分20
1分钟前
1分钟前
1分钟前
宁雨歆完成签到,获得积分10
1分钟前
8R60d8应助端庄闭月采纳,获得10
1分钟前
落后凝莲完成签到,获得积分10
1分钟前
1分钟前
科研通AI2S应助大大小采纳,获得10
1分钟前
落后凝莲发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
SULAIMAN发布了新的文献求助10
1分钟前
阿尔弗雷德完成签到 ,获得积分10
1分钟前
Hayat发布了新的文献求助10
1分钟前
1分钟前
1分钟前
2分钟前
amengptsd完成签到,获得积分10
2分钟前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
How Maoism Was Made: Reconstructing China, 1949-1965 800
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 量子力学 冶金 电极
热门帖子
关注 科研通微信公众号,转发送积分 3316864
求助须知:如何正确求助?哪些是违规求助? 2948687
关于积分的说明 8541803
捐赠科研通 2624574
什么是DOI,文献DOI怎么找? 1436326
科研通“疑难数据库(出版商)”最低求助积分说明 665874
邀请新用户注册赠送积分活动 651796