伊米奎莫德
银屑病
医学
皮肤病科
审查
临床药理学
透视图(图形)
炎症
免疫学
药理学
计算机科学
政治学
人工智能
法学
作者
Jason E. Hawkes,Jóhann E. Guðjónsson,Nicole L. Ward
标识
DOI:10.1016/j.jid.2016.10.024
摘要
Since 2009, the imiquimod- or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of acute skin inflammation has become the most widely used mouse model in preclinical psoriasis studies. Although this model offers researchers numerous benefits, there are important limitations and possible confounding variables to consider. The imiquimod model requires careful consideration and warrants scrutiny of the data generated by its use. In this perspective, we provide an overview of the advantages and disadvantages of this mouse model and offer suggestions for its use in psoriasis research.
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