Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines

Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. Additionally, pyrroloquinoxalines are also important intermediates for the construction of 5-HT3 receptor agonists. In this review the developments in biological activities and synthetic methodologies of pyrroloquinoxalines are discussed. Keywords: 5-HT3 Receptor agonists, anticancer agents, anti-HIV agents, antimalarial agents, PARP-1 inhibitors, pyrroloquinoxalines, synthetic methodologies