Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

O-acetyl and carboxylic functionalities of Auricularia auricula-judae glucuronoxylomannan play critical roles in TLR4/MD2 receptor binding for its immunostimulatory activity.