麦角新碱
米曲霉
化学
粗脉脉孢菌
Erg公司
生物化学
组氨酸
半胱氨酸
基因
发酵
酶
突变体
抗氧化剂
视网膜
作者
Shun Takusagawa,Yasuharu Satoh,Iwao Ohtsu,Tohru Dairi
标识
DOI:10.1080/09168451.2018.1527210
摘要
ABSTRACT To establish a reliable and practical ergothioneine (ERG) supply, we employed fermentative ERG production using Aspergillus oryzae, a fungus used for food production. We heterologously overexpressed the egt-1 and -2 genes of Neurospora crassa in A. oryzae and succeeded in producing ERG (231.0 mg/kg of media, which was 20 times higher than the wild type). Abbreviations: ERG: ergothioneine; HER: hercynine; Cys-HER: hercynylcysteine-sulfoxide; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; l-His: l-histidine; l-Cys: l-cysteine; LC-ESI-MS: liquid chromatography-electrospray ionization-mass spectrometry
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