Clinical Evaluation of Amukkara Chooranam (Internal) and Vettiver Thylam (External) for Kalanjaga Padai (Psoriasis) in Children

Clinical Evaluation of Amukkara chooranam (Internal) and Vettiver thylam (External) for Kalanjaga padai (Psoriasis) in children was done after getting approved by IEC of National Institute of Siddha. [IEC No: NIS/IEC/2016/11- 17/14.10.2016] and the trial is registered in Clinical trial Registry of India with Reg.No CTRI /2017/06/008935 [Registered on: 29/06/2017]. • The raw drugs of Amukkara chooranam and Vettiver thylam were identified and authentication certificate was obtained. • The drug Amukkara choornam was a fine powder pale brownish in colour with strongly aromatic odour. • The drug has a particle size with the range of lowest 46.63 μm to highest 163.3 μm. The loss on drying indicates the moisture content of the drug was determined as 8.3 ± 3.55%. The total ash was found to be 2.64 ± 0.25% which indicates the inorganic content of the drug. The water soluble ash was calculated as 11.87 ± 2.99% and the value of acid insoluble ash was found to be 1.60 ± 0.03% which indicates that the drug contains negligible amount of siliceous matter. The water soluble extractive value and alcohol soluble extractive value were found to be 36.87 ± 1.72% and 36.9 ± 1.38%. The pH value is measured as 5 which indicates that the drug is weekly acidic. • HPTLC was done to identify phyto-chemicals and their Rf values were calculated. • The drug is free of microbial contamination and pesticide residues. • In heavy metals analysis mercury was not detected and lead, arsenic, cadmium were present within the permissible limit. • Aflatoxin like B2, G1, G2 were not detected except B1 which was within the permissible limit. • The disease Kalanjaga padai was taken for the clinical study with Amukkara chooranam (Internal) and Vettiver thylam (External) as a trial medicine and 30 cases were selected based on the approved protocol. • The detailed study of Kalanjaga padai with reference to its etiology, pathogenesis, clinical features, diagnosis and treatment with trial drug was done. • The results were observed by PASI score. Among the 30 cases treated 60% of the cases had very good improvement and 23.33% had good improvement and 16.66% of the cases had moderate improvement. • Statistical Analysis: The Mean Standard Deviation of VASI Score before and after treatment was 20.66 ± 17.36 and 2.39 ± 3.75 respectively which is statistically significant (p < 0.0001). • The analysis reveals that there is 88% reduction in erythema, thickening of skin and scales. CONCLUSION: The poly herbal formulation Amukkara chooranam (Internal) and Vettiver thylam (External) exhibited no toxicity on short term administration in children. • The present clinical study confirms the efficacy and safety of the trial drug ―Amukkara chooranam (Internal) and Vettiver thylam (External)‖ which are Siddha poly herbal formulations respectively. • It was found to be having good result on Kalanjagapadai patients in reducing clinical symptoms like erythema, thickening of skin, scaling. • The Mean Standard Deviation of PASI Score before and after treatment was 20.66 ± 17.36 and 2.39 ± 3.7 respectively which is statistically significant (p < 0.0001). The analysis reveals that there is 88% reduction in erythema, thickening of skin, scling. • From the above results, the trial drug ―Amukkara chooranam (Internal) and Vettiver thylam (External) provides very good improvement in the treatment of Kaalanjaga padai. • The open clinical trial conducted on Kalanjaga padai with the trial drug Amukkara chooranam (Internal) and Vettiver thylam (External) creates a very good impact on the affected area. Hence the author recommends by increasing the trial period for about 90 days will bring out the tremendous effect of the drug in future which will reduce the stress of the affected children and enable to lead a healthy life. • As a conclusion it can be stated that the Siddha Herbal formulation Amukkara chooranam (Internal) and Vettiver thylam (External) can be used as a safe and extremely efficacious drug towards the management of Kalanjaga padai in children which takes a huge toll of inducing psychological stress and impact on the cosmetic purposes.