医学
易普利姆玛
无容量
转移性黑色素瘤
黑色素瘤
肿瘤科
内科学
皮肤病科
免疫疗法
癌症研究
癌症
作者
Hussein Tawbi,Peter Forsyth,Alain P. Algazi,Omid Hamid,F. Stephen Hodi,Stergios J. Moschos,Nikhil I. Khushalani,Karl D. Lewis,Christopher D. Lao,Michael A. Postow,Michael B. Atkins,Marc S. Ernstoff,David A. Reardon,Igor Puzanov,Ragini R. Kudchadkar,Reena Thomas,Ahmad A. Tarhini,Anna C. Pavlick,Joel Jiang,Alexandre Avila,Sheena Demelo,Kim Margolin
标识
DOI:10.1056/nejmoa1805453
摘要
Brain metastases are a common cause of disabling neurologic complications and death in patients with metastatic melanoma. Previous studies of nivolumab combined with ipilimumab in metastatic melanoma have excluded patients with untreated brain metastases. We evaluated the efficacy and safety of nivolumab plus ipilimumab in patients with melanoma who had untreated brain metastases.
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