表观遗传学
生物
表观基因组
重编程
表观遗传疗法
癌变
癌症
基因组学
后生
遗传学
癌症表观遗传学
表观遗传学
计算生物学
生物信息学
DNA甲基化
基因
基因组
基因表达
组蛋白甲基转移酶
作者
Cristiana Libardi Miranda Furtado,Maria Cláudia dos Santos Luciano,Renan da Silva Santos,Gilvan Pessoa Furtado,Manoel Odorico de Moraes,Cláudia Pessoa
出处
期刊:Epigenetics
[Informa]
日期:2019-07-13
卷期号:14 (12): 1164-1176
被引量:228
标识
DOI:10.1080/15592294.2019.1640546
摘要
Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the epigenetic landscape in the cancer epigenome is one of the most promising target therapies in both treatment and reversibility of drug resistance. Epigenetic alterations in cancer development and progression may be the basis for the individual variation in drug response. Thus, this review focuses on the emerging area of pharmaco(epi)genomics, specifically highlighting epigenetic reprogramming during tumorigenesis and how epigenetic markers are targeted as a therapy (epidrugs) and the clinical implications of this for cancer treatment.
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