优势比
丙型肝炎病毒
基因型
置信区间
单核苷酸多态性
等位基因
病毒学
病毒
医学
塔克曼
人口
慢性肝炎
内科学
胃肠病学
生物
基因
遗传学
聚合酶链反应
环境卫生
作者
Xiaobo Zhu,Lingyun Zhuo,Ming Yue,Mei Liu,Feng Zang,Haozhi Fan,Jingjing Wu,Xueshan Xia,A‐Mei Zhang,Rongbin Yu,Peng Huang
摘要
To investigate the association between two RIG-I-like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population.The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non-HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients).IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07-1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15-1.78; P = 0.001) were associated with chronic hepatitis C (CHC). And the risk of CHC increased when people were carrying more unfavorable rs3747517-GA/AA and rs9695310-GC/CC genotypes from zero to two with the chronic rates of 56.72%, 59.38%, and 69.01%, respectively (Ptrend < 0.001).Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population.
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